The result is a solution which enables the automated 24/7 monitoring of glucose while also automating the associated feed control strategy to ensure optimal process control. Today, utilizing the open connectivity of OPC technology, Finesse has successfully integrated their TruBio(TM) OS and DeltaV enabled TruLogic Controller with the On-Line Sampler equipped Bioprofile 400 from Nova Biomedical. This practice has proven itself to be both costly and highly ineffective if trying to achieve true process control. The resulting glucose measurement would then be manually entered into the bioreactor controller and a desired control action initiated. As such, the solution to date has been to locate these glucose enabled chemical analyzers in close proximity to the bioprocess and utilize a manual method by which to extract samples from the bioreactors and deliver them to the analyzer. Sterility and cleaning procedures associated with bioprocess but do successfully measure glucose. These sensors, most often included as one of many measurements found in a modern chemical analyzer, cannot survive the harsh While in-situ sensors for glucose measurement have yet to be successfully introduced, there have existed for some time glucose sensors that are not in- situ.
A process which requires the ability of the sensor to survive not only 131 degrees C Sterilization for periods of 30 minutes or more but often chemical based Clean-In-place (CIP) as well. However, while many have tried, such a sensor has yet to be successfully introduced for the bioprocess.
Historically, the industry has sought an in-situ (In-Line) glucose sensor much like those used for pH and Dissolved Oxygen. The need to automate the practice of on-line glucose monitoring and control can be attributed to the critical role glucose plays in bioprocess applications. This accomplishment joins their earlier accomplishment of automating pH and DO standardization with Nova Biomedical.
Santa Clara, CA - Finesse Solutions, LLC, Santa Clara CA, a manufacturer of measurement and control solutions for life science process applications announced recently that by working closely with Nova Biomedical they have successfully automated on-line glucose monitoring and control.
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